Description
产品说明
| 所属分类 | 微生物 > 模式菌株 |
|---|---|
| 品牌 / 来源 | CS-BIC | 中科生信 |
| 应用 | 科研，生产,产生几丁质酶,产生环孢菌素A S-7481/F-1,产生环孢菌素B S-7481/F-2,产生环孢菌素C,产生环孢菌素D,产生环孢菌素E,产生环孢菌素G,产生环孢菌素合成酶,产生二氢环孢菌素C,产生二氢环孢菌素G,产生异环孢菌素G,产生脂肪酶,转换主机 |
| 培养基 | ATCC® Medium 200: YM agar or YM broth ATCC® Medium 336: Potato dextrose agar (PDA) |
| 存储人 | NRRL |
| 出品公司 | ATCC |
| 分离来源 | 土壤 |
| 参考文献 | Offenzeller M, et al. Biosynthesis of the unusual amino acid (4R)-4-[(E)-2-butenyl]-4-methyl-L-threonine of cyclosporin A. J. Biol. Chem. 268: 26127-26134, 1993. PubMed: 8253730 Ruegger A, Kuhn M. Dihydrocyclosporin C. US Patent 4,108,985 dated Aug 22 1978 Harri E, Ruegger A. Organic compounds. US Patent 4,117,118 dated Sep 26 1978 Traber RP, et al. Cyclosporin derivatives, their production and pharmaceutical compositions containing them. US Patent 4,288,431 dated Sep 8 1981 Weber G, et al. The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame. Curr. Genet. 26: 120-125, 1994. PubMed: 8001164 Weber G, Leitner E. Disruption of the cyclosporin synthetase gene of Tolypocladium niveum. Curr. Genet. 26: 461-467, 1994. PubMed: 7874740 von Arx JA. Tolypocladium, a synomym of Beauveria. Mycotaxon 25: 153-158, 1986. Kempken F, et al. A unique repeated DNA sequence in the cyclosporin-producing strain of Tolypocladium inflatum (ATCC 34921). Exp. Mycol. 19: 305-313, 1995. PubMed: 8574905 Agathos SN, Lee J. Mathematical modeling of the production of cyclosporin A by Tolypocladium inflatum: effect of L-valine. Biotechnol. Prog. 9: 54-63, 1993. PubMed: 7763411 Kempken F, Kuck U. Evidence for circular transposition derivatives from the fungal hAT-transposon Restless. Curr. Genet. 34: 200-203, 1998. PubMed: 9745022 Lee TH, et al. Development of a cell-loaded biosupport separator for continuous immobilized-cell perfusion culture. Biotechnol. Prog. 15: 267-272, 1999. PubMed: 10194403 Ruegger A, et al. Cyclosporin A, a Peptide Metabolite from Trichoderma polysporum (Link ex Pers.) Rifai, with a remarkable immunosuppressive activity. Helv. Chim. Acta 59: 1075-1092, 1976. PubMed: 950308 Traber R, et al. New cyclopeptides from Trichoderma polysporum (Link ex Pers.) Rifai: cyclosporins B, D and E. Helv. Chim. Acta 60: 1568-1578, 1977. PubMed: 561044 Hoppert M, et al. Structure and localization of cyclosporin synthetase, the key enzyme of cyclosporin biosynthesis in Tolypocladiium inflatum. Arch. Microbiol. 176: 285-293, 2001. PubMed: 11685373 Lee J, Agathos SN. Effect of amino acids on the production of cyclosporin A by Tolypocladium inflatum. Biotechnol. Lett. 11: 77-82, 1989. Aarnio TH, Agathos SN. Production of extracellular enzymes and cyclosporin by Tolypocladium inflatum and morphologically related fungi. Biotechnol. Lett. 11: 759-764, 1989. Windhofer F, et al. Ds-like restless deletion derivatives occur in Tolypocladium inflatum and two foreign hosts, Neurospora crassa and Penicillium chrysogenum. Fungal Genet Biol 35: 171-182, 2002. PubMed: 11848679 |
| 模式菌株 | 否 |
| 生长条件 | 24-26℃, 有氧 |
| 菌株特点 | ATCC 34921 Tolypocladium inflatum,丝状真菌 Nucleotide (GenBank) : Z69598 CPA-element Nucleotide (GenBank) : AJ295083 5.8S rRNA and ITS2 Nucleotide (GenBank) : Z28383 cyclosporin synthetase gene Nucleotide (GenBank) : A36768 Sequence 1 from Patent EP0578616. Nucleotide (GenBank) : A36772 Sequence 5 from Patent EP0578616. Nucleotide (GenBank) : A40404 Sequence 31 from Patent WO9425606. Nucleotide (GenBank) : A40406 Sequence 33 from Patent WO9425606. Nucleotide (GenBank) : A40408 Sequence 35 from Patent WO9425606. Nucleotide (GenBank) : A40409 Sequence 36 from Patent WO9425606. Nucleotide (GenBank) : A40410 Sequence 37 from Patent WO9425606. Nucleotide (GenBank) : S80937 lamda clone 6-14, repetitive element Nucleotide (GenBank) : AJ251864 partial tnir1 gene for pathway-specific nitrogen regulator, exons 1-2 Nucleotide (GenBank) : AOHE00000000 Tolypocladium inflatum NRRL8044, whole genome shotgun sequencing project |
| 菌株类型 | Tolypocladium inflatum,丝状真菌,多孢木霉 |
| 菌种又名 | NRRL 8044 [FERM-P 2796] |
| 菌种名称 | ATCC 34921, ATCC34921 |
| 产品目录号 | 34921 |
| 生物安全等级 | 1 |
| 其他保藏库编号 | BCRC33530,ATCC 34921 ;NRRL 8044 ;FERM-P 2796 |
| ATCC34921标准菌株基本信息 | ATCC ATCC 34921, ATCC34921 NRRL 8044 [FERM-P 2796] Tolypocladium inflatum,丝状真菌,多孢木霉 NRRL 土壤 34921 BCRC33530,ATCC 34921 ;NRRL 8044 ;FERM-P 2796 ATCC® Medium 200: YM agar or YM broth ATCC® Medium 336: Potato dextrose agar (PDA) 24-26℃, 有氧 1 否 科研，生产,产生几丁质酶,产生环孢菌素A S-7481/F-1,产生环孢菌素B S-7481/F-2,产生环孢菌素C,产生环孢菌素D,产生环孢菌素E,产生环孢菌素G,产生环孢菌素合成酶,产生二氢环孢菌素C,产生二氢环孢菌素G,产生异环孢菌素G,产生脂肪酶,转换主机 ATCC 34921 Tolypocladium inflatum,丝状真菌 Nucleotide (GenBank) : Z69598 CPA-element Nucleotide (GenBank) : AJ295083 5.8S rRNA and ITS2 Nucleotide (GenBank) : Z28383 cyclosporin synthetase gene Nucleotide (GenBank) : A36768 Sequence 1 from Patent EP0578616. Nucleotide (GenBank) : A36772 Sequence 5 from Patent EP0578616. Nucleotide (GenBank) : A40404 Sequence 31 from Patent WO9425606. Nucleotide (GenBank) : A40406 Sequence 33 from Patent WO9425606. Nucleotide (GenBank) : A40408 Sequence 35 from Patent WO9425606. Nucleotide (GenBank) : A40409 Sequence 36 from Patent WO9425606. Nucleotide (GenBank) : A40410 Sequence 37 from Patent WO9425606. Nucleotide (GenBank) : S80937 lamda clone 6-14, repetitive element Nucleotide (GenBank) : AJ251864 partial tnir1 gene for pathway-specific nitrogen regulator, exons 1-2 Nucleotide (GenBank) : AOHE00000000 Tolypocladium inflatum NRRL8044, whole genome shotgun sequencing project Offenzeller M, et al. Biosynthesis of the unusual amino acid (4R)-4-[(E)-2-butenyl]-4-methyl-L-threonine of cyclosporin A. J. Biol. Chem. 268: 26127-26134, 1993. PubMed: 8253730 Ruegger A, Kuhn M. Dihydrocyclosporin C. US Patent 4,108,985 dated Aug 22 1978 Harri E, Ruegger A. Organic compounds. US Patent 4,117,118 dated Sep 26 1978 Traber RP, et al. Cyclosporin derivatives, their production and pharmaceutical compositions containing them. US Patent 4,288,431 dated Sep 8 1981 Weber G, et al. The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame. Curr. Genet. 26: 120-125, 1994. PubMed: 8001164 Weber G, Leitner E. Disruption of the cyclosporin synthetase gene of Tolypocladium niveum. Curr. Genet. 26: 461-467, 1994. PubMed: 7874740 von Arx JA. Tolypocladium, a synomym of Beauveria. Mycotaxon 25: 153-158, 1986. Kempken F, et al. A unique repeated DNA sequence in the cyclosporin-producing strain of Tolypocladium inflatum (ATCC 34921). Exp. Mycol. 19: 305-313, 1995. PubMed: 8574905 Agathos SN, Lee J. Mathematical modeling of the production of cyclosporin A by Tolypocladium inflatum: effect of L-valine. Biotechnol. Prog. 9: 54-63, 1993. PubMed: 7763411 Kempken F, Kuck U. Evidence for circular transposition derivatives from the fungal hAT-transposon Restless. Curr. Genet. 34: 200-203, 1998. PubMed: 9745022 Lee TH, et al. Development of a cell-loaded biosupport separator for continuous immobilized-cell perfusion culture. Biotechnol. Prog. 15: 267-272, 1999. PubMed: 10194403 Ruegger A, et al. Cyclosporin A, a Peptide Metabolite from Trichoderma polysporum (Link ex Pers.) Rifai, with a remarkable immunosuppressive activity. Helv. Chim. Acta 59: 1075-1092, 1976. PubMed: 950308 Traber R, et al. New cyclopeptides from Trichoderma polysporum (Link ex Pers.) Rifai: cyclosporins B, D and E. Helv. Chim. Acta 60: 1568-1578, 1977. PubMed: 561044 Hoppert M, et al. Structure and localization of cyclosporin synthetase, the key enzyme of cyclosporin biosynthesis in Tolypocladiium inflatum. Arch. Microbiol. 176: 285-293, 2001. PubMed: 11685373 Lee J, Agathos SN. Effect of amino acids on the production of cyclosporin A by Tolypocladium inflatum. Biotechnol. Lett. 11: 77-82, 1989. Aarnio TH, Agathos SN. Production of extracellular enzymes and cyclosporin by Tolypocladium inflatum and morphologically related fungi. Biotechnol. Lett. 11: 759-764, 1989. Windhofer F, et al. Ds-like restless deletion derivatives occur in Tolypocladium inflatum and two foreign hosts, Neurospora crassa and Penicillium chrysogenum. Fungal Genet Biol 35: 171-182, 2002. PubMed: 11848679 |
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